NRG3 Recombinant Rabbit mAb
Cat No.: ARM1385
Size：
| Product Name: | NRG3 Recombinant Rabbit mAb |
| Cat No.: | ARM1385 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,FC |
| clonality: | Monoclonal |
| recommended dilution: | WB,FC |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human NRG3 |
| calculated molecular weight: | 78 kDa |
| observed molecular weight: | 55 kDa |
| genbank accession number: | P56975 |
| gene id (ncbi): | 10718 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | HRG3; pro-NRG3 |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009] |