EWSR1 Recombinant Rabbit mAb
Cat No.: ARM1331
Size：
| Product Name: | EWSR1 Recombinant Rabbit mAb |
| Cat No.: | ARM1331 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IHC,ICC/IF |
| clonality: | Monoclonal |
| recommended dilution: | WB,IHC,ICC/IF |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human EWSR1 |
| calculated molecular weight: | 69 kDa |
| observed molecular weight: | 85 kDa |
| genbank accession number: | Q01844 |
| gene id (ncbi): | 2130 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | EWS; EWS-FLI1; bK984G1.4 |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009] |