Notch1 Recombinant Rabbit mAb
Cat No.: ARM1262
Size：
| Product Name: | Notch1 Recombinant Rabbit mAb |
| Cat No.: | ARM1262 |
| source: | Rabbit |
| reactivity: | Human, Mouse |
| applications: | WB,IHC,ICC/IF,FC |
| clonality: | Monoclonal |
| recommended dilution: | WB,IHC,ICC/IF,FC |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Notch1 |
| calculated molecular weight: | 273 kDa |
| observed molecular weight: | 120 kDa |
| genbank accession number: | P46531 |
| gene id (ncbi): | 4851 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | hN1; AOS5; TAN1; AOVD1 |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016] |