Nicastrin Recombinant Rabbit mAb
Cat No.: ARM1236
Size：
| Product Name: | Nicastrin Recombinant Rabbit mAb |
| Cat No.: | ARM1236 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,FC,IP |
| clonality: | Monoclonal |
| recommended dilution: | WB,FC,IP |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Nicastrin |
| calculated molecular weight: | 78 kDa |
| observed molecular weight: | 110-120 kDa |
| genbank accession number: | Q92542 |
| gene id (ncbi): | 23385 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | ATAG1874 |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer--s disease; however, the nature of the encoded protein--s role in Alzheimer--s disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014] |