PKR Recombinant Rabbit mAb
Cat No.: ARM1187
Size：
| Product Name: | PKR Recombinant Rabbit mAb |
| Cat No.: | ARM1187 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,ICC/IF,FC,IP |
| clonality: | Monoclonal |
| recommended dilution: | WB,ICC/IF,FC,IP |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of mouse PKR |
| calculated molecular weight: | 62 kDa |
| observed molecular weight: | 74 kDa |
| genbank accession number: | Q03963 |
| gene id (ncbi): | 19106 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | Pkr; Tik; Prkr; AI467567; AI747578; 2310047A08Rik; 4732414G15Rik |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. |