P Glycoprotein Recombinant Rabbit mAb
Cat No.: ARM1082
Size：
| Product Name: | P Glycoprotein Recombinant Rabbit mAb |
| Cat No.: | ARM1082 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,IHC |
| clonality: | Monoclonal |
| recommended dilution: | WB,IHC |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human P Glycoprotein |
| calculated molecular weight: | 142 kDa |
| observed molecular weight: | 130-180 kDa |
| genbank accession number: | P08183 |
| gene id (ncbi): | 5243 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170 |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017] |