PPP4C Recombinant Rabbit mAb
Cat No.: ARM1075
Size：
| Product Name: | PPP4C Recombinant Rabbit mAb |
| Cat No.: | ARM1075 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IHC,FC |
| clonality: | Monoclonal |
| recommended dilution: | WB,IHC,FC |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human PPP4C |
| calculated molecular weight: | 35 kDa |
| observed molecular weight: | 35 kDa |
| genbank accession number: | P60510 |
| gene id (ncbi): | 5531 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | PP4; PPX; PP-X; PP4C; PPH3; PPP4 |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. |