Doublecortin Recombinant Rabbit mAb
Cat No.: ARM1025
Size：
| Product Name: | Doublecortin Recombinant Rabbit mAb |
| Cat No.: | ARM1025 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IHC,ICC/IF |
| clonality: | Monoclonal |
| recommended dilution: | WB,IHC,ICC/IF |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human Doublecortin |
| calculated molecular weight: | 41 kDa |
| observed molecular weight: | 41 kDa |
| genbank accession number: | O43602 |
| gene id (ncbi): | 1641 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | DC; DBCN; LISX; SCLH; XLIS |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] |