MCM3 Recombinant Rabbit mAb
Cat No.: ARM2909
Size:
Product Name: | MCM3 Recombinant Rabbit mAb |
Cat No.: | ARM2909 |
source: | Rabbit |
reactivity: | Human, Mouse, Rat |
applications: | WB, IHC, ICC/IF, FC |
clonality: | Monoclonal |
recommended dilution: | WB, IHC, ICC/IF, FC |
format: | Liquid |
isotype: | IgG |
immunogen: | A synthetic peptide of human MCM3 |
calculated molecular weight: | 91 kDa |
observed molecular weight: | 100 kDa |
genbank accession number: | P25205 |
gene id (ncbi): | 4172 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | HCC5; P1.h; RLFB; P1-MCM3 |
category: | Primary Ab |
concentration: | 1mg/ml |
background: | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012] |