Axin 2 Recombinant Rabbit mAb
Cat No.: ARM2798
Size:
Product Name: | Axin 2 Recombinant Rabbit mAb |
Cat No.: | ARM2798 |
source: | Rabbit |
reactivity: | Human, Mouse, Rat |
applications: | WB, IHC, ICC/IF |
clonality: | Monoclonal |
recommended dilution: | WB, IHC, ICC/IF |
format: | Liquid |
isotype: | IgG |
immunogen: | A synthetic peptide of human Axin 2 |
calculated molecular weight: | 94 kDa |
observed molecular weight: | 94 kDa |
genbank accession number: | Q9Y2T1 |
gene id (ncbi): | 8313 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | AXIL; ODCRCS |
category: | Primary Ab |
concentration: | 1mg/ml |
background: | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] |