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ATF5 Recombinant Rabbit mAb

Cat No.: ARM2793
Size:
Product Name: ATF5 Recombinant Rabbit mAb
Cat No.: ARM2793
source: Rabbit
reactivity: Human, Mouse, Rat
applications: WB, IHC, ICC/IF, FC, IP
clonality: Monoclonal
recommended dilution: WB, IHC, ICC/IF, FC, IP
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human ATF5
calculated molecular weight: 31 kDa
observed molecular weight: 31 kDa
genbank accession number: Q9Y2D1
gene id (ncbi): 22809
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: ATFX; HMFN0395
category: Primary Ab
concentration: 1mg/ml
background: Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5---GTGACGT[AC][AG]-3--), ATF5-specific response element (ARE) (consensus: 5---C[CT]TCT[CT]CCTT[AT]-3--) but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity).