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NEDD8 Recombinant Rabbit mAb

Cat No.: ARM2786
Size:
Product Name: NEDD8 Recombinant Rabbit mAb
Cat No.: ARM2786
source: Rabbit
reactivity: Human, Mouse, Rat
applications: WB, IHC, ICC/IF, FC, IP
clonality: Monoclonal
recommended dilution: WB, IHC, ICC/IF, FC, IP
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human NEDD8
calculated molecular weight: 9 kDa
observed molecular weight: 9 kDa
genbank accession number: Q15843
gene id (ncbi): 4738
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: NEDD-8
category: Primary Ab
concentration: 1mg/ml
background: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.