Pyruvate Dehydrogenase E1 alpha Recombinant Rabbit mAb
Cat No.: ARM2783
Size:
Product Name: | Pyruvate Dehydrogenase E1 alpha Recombinant Rabbit mAb |
Cat No.: | ARM2783 |
source: | Rabbit |
reactivity: | Human, Mouse, Rat |
applications: | WB, IHC, ICC/IF, FC, IP |
clonality: | Monoclonal |
recommended dilution: | WB, IHC, ICC/IF, FC, IP |
format: | Liquid |
isotype: | IgG |
immunogen: | A synthetic peptide of human Pyruvate Dehydrogenase E1-alpha subunit |
calculated molecular weight: | 43 kDa |
observed molecular weight: | 43 kDa |
genbank accession number: | P08559 |
gene id (ncbi): | 5160 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | PDHA; PDHAD; PHE1A; PDHCE1A |
category: | Primary Ab |
concentration: | 1mg/ml |
background: | The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010] |