MBD2 Recombinant Rabbit mAb
Cat No.: ARM2768
Size：
| Product Name: | MBD2 Recombinant Rabbit mAb |
| Cat No.: | ARM2768 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB, IHC, ICC/IF, FC, IP |
| clonality: | Monoclonal |
| recommended dilution: | WB, IHC, ICC/IF, FC, IP |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human MBD2 |
| calculated molecular weight: | 43 kDa |
| observed molecular weight: | 43 kDa |
| genbank accession number: | Q9UBB5 |
| gene id (ncbi): | 8932 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | DMTase; NY-CO-41 |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] |