CDT2 Recombinant Rabbit mAb
Cat No.: ARM2753
Size：
| Product Name: | CDT2 Recombinant Rabbit mAb |
| Cat No.: | ARM2753 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB, IHC, ICC/IF, FC |
| clonality: | Monoclonal |
| recommended dilution: | WB, IHC, ICC/IF, FC |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human CDT2 |
| calculated molecular weight: | 80 kDa |
| observed molecular weight: | 80 kDa |
| genbank accession number: | Q9NZJ0 |
| gene id (ncbi): | 51514 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | CDT2; RAMP; DCAF2; L2DTL |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBXO18/FBH1 and KMT5A (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). |