SFPQ Recombinant Rabbit mAb
Cat No.: ARM2666
Size：
| Product Name: | SFPQ Recombinant Rabbit mAb |
| Cat No.: | ARM2666 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB, IHC, ICC/IF |
| clonality: | Monoclonal |
| recommended dilution: | WB, IHC, ICC/IF |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human SFPQ |
| calculated molecular weight: | 76 kDa |
| observed molecular weight: | 100 kDa |
| genbank accession number: | P23246 |
| gene id (ncbi): | 6421 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | PSF; POMP100; PPP1R140 |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. |