NLRP3 Recombinant Rabbit mAb
Cat No.: ARM2558
Size：
| Product Name: | NLRP3 Recombinant Rabbit mAb |
| Cat No.: | ARM2558 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB |
| clonality: | Monoclonal |
| recommended dilution: | WB |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human NLRP3 |
| calculated molecular weight: | 118 kDa |
| observed molecular weight: | 118 kDa |
| genbank accession number: | Q96P20 |
| gene id (ncbi): | 114548 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | AII; AVP; FCU; MWS; FCAS; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5-- UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5-- UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008] |