SLAMF7 Rabbit pAb
Cat No.: APA3709
Size：
| Product Name: | SLAMF7 Rabbit pAb |
| Cat No.: | APA3709 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,IHC,IP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IHC: 1:500 IP: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human SLAMF7 |
| calculated molecular weight: | 37 kDa |
| observed molecular weight: | 37 kDa |
| genbank accession number: | Q9NQ25 |
| gene id (ncbi): | 57823 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | 19A; CS1; CD319; CRACC |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). |