NKCC2 Rabbit pAb
Cat No.: APA2629
Size：
| Product Name: | NKCC2 Rabbit pAb |
| Cat No.: | APA2629 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,FC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 FC: 1:20-1:100 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human NKCC2 |
| calculated molecular weight: | 122 kDa |
| observed molecular weight: | 150 kDa |
| genbank accession number: | Q13621 |
| gene id (ncbi): | 6557 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | BSC1; NKCC2 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle--s loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010] |