MHC Class II beta Rabbit pAb
Cat No.: APA2007

Product Name: | MHC Class II beta Rabbit pAb |
Cat No.: | APA2007 |
source: | Rabbit |
reactivity: | Human |
applications: | WB,IHC,ICC/IF |
clonality: | Polyclonal |
recommended dilution: | WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 |
format: | Liquid |
isotype: | IgG |
immunogen: | A synthetic peptide of human MHC Class II beta |
calculated molecular weight: | 29 kDa |
observed molecular weight: | 29 kDa |
genbank accession number: | P04440 |
gene id (ncbi): | 3115 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | DPB1; HLA-DP; HLA-DPB; HLA-DP1B |
category: | Primary Ab |
concentration: | 0.5mg/ml |
background: | HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008] |