Hamartin Rabbit pAb
Cat No.: APA1935
Size：
| Product Name: | Hamartin Rabbit pAb |
| Cat No.: | APA1935 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,IHC,FC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:5000 IHC: 1:20 FC: 1:200-1:1000 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Hamartin |
| calculated molecular weight: | 130 kDa |
| observed molecular weight: | 150-170 kDa |
| genbank accession number: | Q92574 |
| gene id (ncbi): | 7248 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | LAM; TSC |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018] |