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PE/Cyanine7 Anti-Mouse CD51 Antibody[RMV-7]

Cat No.: FCE3617
Size:
Product Name: PE/Cyanine7 Anti-Mouse CD51 Antibody[RMV-7]
Cat No.: FCE3617
host: Rat
uniprot id: P43406
geneid: 16410
application: FCM
isotype: Rat IgG1, κ
form: Liquid
storage: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
shipping: Ice bag
category id: Flow Cytometry Antibodies
abbreviation: CD51
conjugation: PE/Cyanine7
species reactivity: Mouse
usage: Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/10^6 cells in 100 μL volume].
clone no.: RMV-7
background: CD51 is a 140 kD protein, also known as αV?integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5?or β6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αvintegrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.
target synonym: Integrin alpha-V;αV integrin;Vitronectin Receptor;Integrin αV chain;ITGAV;
concentration: 0.2 mg/mL
buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
image 1 description: C57BL/6 murine bone marrow cells are stained with PE/Cyanine7 Anti-Mouse CD51 Antibody (filled gray histogram). Unstained bone marrow cells (empty black histogram) are used as control.
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