APC Anti-Mouse CD51 Antibody[RMV-7]
Cat No.: FCE3616
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| Product Name: | APC Anti-Mouse CD51 Antibody[RMV-7] |
| Cat No.: | FCE3616 |
| host: | Rat |
| uniprot id: | P43406 |
| geneid: | 16410 |
| application: | FCM |
| isotype: | Rat IgG1, κ |
| form: | Liquid |
| storage: | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| shipping: | Ice bag |
| category id: | Flow Cytometry Antibodies |
| abbreviation: | CD51 |
| conjugation: | APC |
| species reactivity: | Mouse |
| usage: | Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/10^6 cells in 100 μL volume]. |
| clone no.: | RMV-7 |
| background: | CD51 is a 140 kD protein, also known as αV?integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5?or β6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αvintegrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity. |
| target synonym: | Integrin alpha-V;αV integrin;Vitronectin Receptor;Integrin αV chain;ITGAV; |
| concentration: | 0.2 mg/mL |
| buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| image 1 description: | C57BL/6 murine bone marrow cells are stained with APC Anti-Mouse CD51 Antibody (Left). Bone marrow cells are stained with APC Rat IgG1, κ Isotype Control (Right). |