Biotin Anti-Mouse CD51 Antibody[RMV-7]
Cat No.: FCE3611
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| Product Name: | Biotin Anti-Mouse CD51 Antibody[RMV-7] |
| Cat No.: | FCE3611 |
| host: | Rat |
| uniprot id: | P43406 |
| geneid: | 16410 |
| application: | FCM |
| isotype: | Rat IgG1, κ |
| form: | Liquid |
| storage: | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| shipping: | Ice bag |
| category id: | Flow Cytometry Antibodies |
| abbreviation: | CD51 |
| conjugation: | Biotin |
| species reactivity: | Mouse |
| usage: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| clone no.: | RMV-7 |
| background: | CD51 is a 140 kD protein, also known as αV?integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5?or β6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αvintegrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity. |
| target synonym: | Integrin alpha-V;αV integrin;Vitronectin Receptor;Integrin αV chain;ITGAV; |
| concentration: | 0.5 mg/mL |
| buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| image 1 description: | C57BL/6 murine bone marrow cells are stained with Biotin Anti-Mouse CD51 Antibody followed by Streptavidin- Fluor® 647 (Left). Bone marrow cells are stained with Biotin Rat IgG1, κ Isotype Control followed by Streptavidin- Fluor® 647 (Right). |
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