PE Anti-Mouse CD105 Antibody[MJ7/18]
Cat No.: FCE3603
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| Product Name: | PE Anti-Mouse CD105 Antibody[MJ7/18] |
| Cat No.: | FCE3603 |
| host: | Rat |
| uniprot id: | Q63961 |
| geneid: | 13805 |
| application: | FCM |
| isotype: | Rat IgG2a, κ |
| form: | Liquid |
| storage: | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| shipping: | Ice bag |
| category id: | Flow Cytometry Antibodies |
| abbreviation: | CD105 |
| conjugation: | PE |
| species reactivity: | Mouse |
| usage: | Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/10^6 cells in 100 μL volume]. |
| clone no.: | MJ7/18 |
| background: | CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases. |
| target synonym: | Endoglin;END;Eng; |
| concentration: | 0.2 mg/mL |
| buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| image 1 description: | Mouse endothelial cells (bEnd.3) are stained with PE Anti-Mouse CD105 Antibody (filled gray histogram). PE Mouse IgG2a, κ Isotype Control stained cells are used as control. |
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