Biotin Anti-Mouse IL-17A Antibody[TC11-18H10.1]
Cat No.: FCE3397
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| Product Name: | Biotin Anti-Mouse IL-17A Antibody[TC11-18H10.1] |
| Cat No.: | FCE3397 |
| host: | Rat |
| uniprot id: | Q62386 |
| geneid: | 16171 |
| application: | ICFCM |
| isotype: | Rat IgG1, κ |
| form: | Liquid |
| storage: | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| shipping: | Ice bag |
| category id: | Flow Cytometry Antibodies |
| abbreviation: | IL-17A |
| conjugation: | Biotin |
| species reactivity: | Mouse |
| usage: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| clone no.: | TC11-18H10.1 |
| background: | IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. |
| target synonym: | Interleukin-17A;IL-17;IL-17A;Cytotoxic T-lymphocyte-associated antigen 8;CTLA-8;CTLA8; |
| concentration: | 0.5 mg/mL |
| buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
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