Biotin Anti-Human CD127/IL-7RA Antibody[A019D5]
Cat No.: FCE2999
Size：
| Product Name: | Biotin Anti-Human CD127/IL-7RA Antibody[A019D5] |
| Cat No.: | FCE2999 |
| host: | Mouse |
| uniprot id: | P16871 |
| geneid: | 3575 |
| application: | FCM |
| isotype: | Mouse IgG1, κ |
| form: | Liquid |
| storage: | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| shipping: | Ice bag |
| category id: | Flow Cytometry Antibodies |
| abbreviation: | CD127/IL-7RA |
| conjugation: | Biotin |
| species reactivity: | Human |
| usage: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| clone no.: | A019D5 |
| background: | CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development. |
| target synonym: | Interleukin-7 receptor subunit alpha;IL-7RA;CDw127;CD127;IL-7Rα; |
| concentration: | 0.5 mg/mL |
| buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| image 1 description: | Human peripheral blood lymphocytes are stained with FITC Anti-Human CD3 Antibody and Biotin Anti-Human CD127/IL-7RA Antibody followed by Streptavidin- Fluor® 647 (Left). Lymphocytes are stained with FITC Anti-Human CD3 Antibody and Biotin Mouse Rat IgG1, κ Isotype Control followed by with Streptavidin- Fluor® 647 (Right). |