PE Fluor® 594 Anti-Human CD107a/LAMP-1 Antibody[H4A3]
Cat No.: FCE2991
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| Product Name: | PE Fluor® 594 Anti-Human CD107a/LAMP-1 Antibody[H4A3] |
| Cat No.: | FCE2991 |
| host: | Mouse |
| uniprot id: | P11279 |
| geneid: | 3916 |
| application: | FCM |
| isotype: | Mouse IgG1, κ |
| form: | Liquid |
| storage: | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| shipping: | Ice bag |
| category id: | Flow Cytometry Antibodies |
| abbreviation: | CD107a/LAMP-1 |
| conjugation: | PE/ Fluor® 594 |
| species reactivity: | Human |
| usage: | Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. |
| clone no.: | H4A3 |
| background: | CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+?T cell and NK cell cytotoxicity. |
| target synonym: | Lysosome-Associated Membrane Protein 1; LGP-120; LAMP-1; |
| concentration: | 5 μL/Test |
| buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| image 1 description: | Intracellular staining of the Jurkat cell line with PE/ Fluor® 594 Anti-Human CD107a/LAMP-1 Antibody (filled gray histogram) or PE/ Fluor® 594 Mouse IgG1, κ Isotype Control (empty black histogram). |