APC Anti-Mouse CD206/MMR Antibody[C068C2]
Cat No.: FCE2849
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| Product Name: | APC Anti-Mouse CD206/MMR Antibody[C068C2] |
| Cat No.: | FCE2849 |
| host: | Rat |
| uniprot id: | Q61830 |
| geneid: | 17533 |
| application: | FCM,ICFCM |
| isotype: | Rat IgG2a, κ |
| form: | Liquid |
| storage: | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| shipping: | Ice bag |
| category id: | Flow Cytometry Antibodies |
| abbreviation: | CD206/MMR |
| conjugation: | APC |
| species reactivity: | Mouse |
| usage: | Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/10^6 cells in 100 μL volume]. |
| clone no.: | C068C2 |
| background: | CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature. |
| target synonym: | MMR;MR;MRC1;macrophage mannose receptor;mannose receptor ; |
| concentration: | 0.2 mg/mL |
| buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| image 1 description: | C57BL/6 murine abdominal macrophages elicited by starch broth are stained with FITC Anti-Mouse F4/80 Antibody and APC Anti-Mouse CD206 Antibody (Left). Abdominal macrophages are stained with FITC Anti-Mouse F4/80 Antibody and APC Rat IgG2a, κ Isotype Control (Right). |
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