PE/Cyanine7 Anti-Human CD274/PD-L1 Antibody[29E.2A3]
Cat No.: FCE2841
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| Product Name: | PE/Cyanine7 Anti-Human CD274/PD-L1 Antibody[29E.2A3] |
| Cat No.: | FCE2841 |
| host: | Mouse |
| uniprot id: | Q9NZQ7 |
| geneid: | 29126 |
| application: | FCM |
| isotype: | Mouse IgG2b, κ |
| form: | Liquid |
| storage: | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| shipping: | Ice bag |
| category id: | Flow Cytometry Antibodies |
| abbreviation: | PD-L1 |
| conjugation: | PE/Cyanine7 |
| species reactivity: | Human |
| usage: | Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. |
| clone no.: | 29E.2A3 |
| background: | CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. |
| target synonym: | B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1; |
| concentration: | 5 μL/Test |
| buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| image 1 description: | PHA-stimulated (3 days) human peripheral blood lymphocytes are stained with PE/Cyanine7 Anti-Human CD274/PD-L1 Antibody (filled gray histogram) or Mouse IgG1 Isotype Control PE/Cyanine7 (empty black histogram). |