AF/LE Purified Anti-Mouse CD279/PD-1 Antibody[29F.1A12]
Cat No.: FCE2802
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| Product Name: | AF/LE Purified Anti-Mouse CD279/PD-1 Antibody[29F.1A12] |
| Cat No.: | FCE2802 |
| host: | Rat |
| uniprot id: | Q02242 |
| geneid: | 18566 |
| application: | FCM,Block,Neut |
| isotype: | Rat IgG2a, κ |
| form: | Liquid |
| storage: | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| shipping: | Ice bag |
| category id: | Flow Cytometry Antibodies |
| abbreviation: | CD279/PD-1 |
| conjugation: | None (Purified antibody-Azide Free/Low endotoxin) |
| species reactivity: | Mouse |
| usage: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| clone no.: | 29F.1A12 |
| background: | CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts. |
| target synonym: | PD-1; Programmed Death-1; |
| concentration: | 0.5 mg/mL |
| buffer: | 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay. |
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