Purified Anti-Mouse CD54 Antibody[YN1/1.7.4]
Cat No.: FCE1633
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| Product Name: | Purified Anti-Mouse CD54 Antibody[YN1/1.7.4] |
| Cat No.: | FCE1633 |
| host: | Rat |
| uniprot id: | P13597 |
| geneid: | 15894 |
| application: | FCM |
| isotype: | Rat IgG2b, κ |
| form: | Liquid |
| storage: | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| shipping: | Ice bag |
| category id: | Flow Cytometry Antibodies |
| abbreviation: | CD54 |
| conjugation: | Unconjugated |
| species reactivity: | Mouse |
| usage: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| clone no.: | YN1/1.7.4 |
| background: | CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues. |
| target synonym: | Intercellular adhesion molecule 1;Icam1;MALA-2;MyD10;CD54;Icam-1; |
| concentration: | 0.5 mg/mL |
| buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
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