p18 INK4c Recombinant Rabbit mAb
Cat No.: ARM1554
Size：
| Product Name: | p18 INK4c Recombinant Rabbit mAb |
| Cat No.: | ARM1554 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IHC,ICC/IF,IP |
| clonality: | Monoclonal |
| recommended dilution: | WB,IHC,ICC/IF,IP |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human p18 INK4c |
| calculated molecular weight: | 18 kDa |
| observed molecular weight: | 18 kDa |
| genbank accession number: | P42773 |
| gene id (ncbi): | 1031 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | p18; INK4C; p18-INK4C |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008] |