Epac1 Recombinant Rabbit mAb
Cat No.: ARM2829
Size:
Product Name: | Epac1 Recombinant Rabbit mAb |
Cat No.: | ARM2829 |
source: | Rabbit |
reactivity: | Human, Mouse, Rat |
applications: | WB, IHC, ICC/IF, IP |
clonality: | Monoclonal |
recommended dilution: | WB, IHC, ICC/IF, IP |
format: | Liquid |
isotype: | IgG |
immunogen: | A synthetic peptide of human Epac1 |
calculated molecular weight: | 104 kDa |
observed molecular weight: | 104 kDa |
genbank accession number: | O95398 |
gene id (ncbi): | 10411 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI |
category: | Primary Ab |
concentration: | 1mg/ml |
background: | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. |