MCM4 Recombinant Rabbit mAb
Cat No.: ARM2295
Size：
| Product Name: | MCM4 Recombinant Rabbit mAb |
| Cat No.: | ARM2295 |
| source: | Rabbit |
| reactivity: | Human, Mouse |
| applications: | WB,FC,IP |
| clonality: | Monoclonal |
| recommended dilution: | WB,FC,IP |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human MCM4 |
| calculated molecular weight: | 97 kDa |
| observed molecular weight: | 97 kDa |
| genbank accession number: | P33991 |
| gene id (ncbi): | 4173 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | NKCD; CDC21; CDC54; IMD54; NKGCD; hCdc21; P1-CDC21 |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |