Cadherin 10 Recombinant Rabbit mAb
Cat No.: ARM2270
Size：
| Product Name: | Cadherin 10 Recombinant Rabbit mAb |
| Cat No.: | ARM2270 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,FC |
| clonality: | Monoclonal |
| recommended dilution: | WB,FC |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human cadherin 10 |
| calculated molecular weight: | 89 kDa |
| observed molecular weight: | 110 kDa |
| genbank accession number: | Q9Y6N8 |
| gene id (ncbi): | 1008 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | T2-cadherin; CDH10 |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein--s homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015] |