FEN1 Recombinant Rabbit mAb
Cat No.: ARM2118
Size：
| Product Name: | FEN1 Recombinant Rabbit mAb |
| Cat No.: | ARM2118 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IHC |
| clonality: | Monoclonal |
| recommended dilution: | WB,IHC |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human FEN1 |
| calculated molecular weight: | 43 kDa |
| observed molecular weight: | 43 kDa |
| genbank accession number: | P39748 |
| gene id (ncbi): | 2237 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | MF1; RAD2; FEN-1 |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | The protein encoded by this gene removes 5-- overhanging flaps in DNA repair and processes the 5-- ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5-- end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008] |