Phospholamban Recombinant Rabbit mAb
Cat No.: ARM1956
Size：
| Product Name: | Phospholamban Recombinant Rabbit mAb |
| Cat No.: | ARM1956 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IHC,IP |
| clonality: | Monoclonal |
| recommended dilution: | WB,IHC,IP |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human Phospholamban |
| calculated molecular weight: | 6 kDa |
| observed molecular weight: | 12,24 kDa |
| genbank accession number: | P26678 |
| gene id (ncbi): | 5350 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | PLB; CMD1P; CMH18 |
| category: | Primary Ab |
| concentration: | 1mg/ml |
| background: | The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016] |