FADD Rabbit pAb
Cat No.: APA1294
Size：
| Product Name: | FADD Rabbit pAb |
| Cat No.: | APA1294 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,IHC,ICC/IF,FC,IP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000-1:5000 IHC: 1:20-1:100 ICC/IF: 1:20-1:50 FC: 1:20 IP: 1:20-1:50 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human FADD |
| calculated molecular weight: | 23 kDa |
| observed molecular weight: | 28 kDa |
| genbank accession number: | Q13158 |
| gene id (ncbi): | 8772 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | GIG3; MORT1 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] |