Epac1 Rabbit pAb
Cat No.: APA1293
Size：
| Product Name: | Epac1 Rabbit pAb |
| Cat No.: | APA1293 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IHC,ICC/IF,IP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:2000 IHC: 1:20 ICC/IF: 1:20 IP: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Epac1 |
| calculated molecular weight: | 104 kDa |
| observed molecular weight: | 104 kDa |
| genbank accession number: | O95398 |
| gene id (ncbi): | 10411 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. |