PKC delta Rabbit pAb
Cat No.: APA1236
Size：
| Product Name: | PKC delta Rabbit pAb |
| Cat No.: | APA1236 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IHC,ICC/IF,FC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IHC: 1:20-1:500 ICC/IF: 1:100 FC: 1:50 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human PKC delta |
| calculated molecular weight: | 78 kDa |
| observed molecular weight: | 78 kDa |
| genbank accession number: | P28867 |
| gene id (ncbi): | 18753 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | Pkcd; PKC[d]; AI385711; PKCdelta; D14Ertd420e |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. |