ULK3 Rabbit pAb
Cat No.: APA1206
Size：
| Product Name: | ULK3 Rabbit pAb |
| Cat No.: | APA1206 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,IHC,ICC/IF,FC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000-1:5000 IHC: 1:20-1:50 ICC/IF: 1:20-1:50 FC: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human ULK3 |
| calculated molecular weight: | 53 kDa |
| observed molecular weight: | 53 kDa |
| genbank accession number: | Q6PHR2 |
| gene id (ncbi): | 25989 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | Unc-51-like kinase 3 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. |