SFPQ Rabbit pAb
Cat No.: APA1107
Size:
Product Name: | SFPQ Rabbit pAb |
Cat No.: | APA1107 |
source: | Rabbit |
reactivity: | Human, Mouse, Rat |
applications: | WB,IHC,ICC/IF |
clonality: | Polyclonal |
recommended dilution: | WB: 1:2000-1:10000 IHC: 1:50 ICC/IF: 1:20 |
format: | Liquid |
isotype: | IgG |
immunogen: | A synthetic peptide of human SFPQ |
calculated molecular weight: | 76 kDa |
observed molecular weight: | 100 kDa |
genbank accession number: | P23246 |
gene id (ncbi): | 6421 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | PSF; POMP100; PPP1R140 |
category: | Primary Ab |
concentration: | 0.5mg/ml |
background: | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. |