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SFPQ Rabbit pAb

Cat No.: APA1107
Size:
Product Name: SFPQ Rabbit pAb
Cat No.: APA1107
source: Rabbit
reactivity: Human, Mouse, Rat
applications: WB,IHC,ICC/IF
clonality: Polyclonal
recommended dilution: WB: 1:2000-1:10000
IHC: 1:50
ICC/IF: 1:20
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human SFPQ
calculated molecular weight: 76 kDa
observed molecular weight: 100 kDa
genbank accession number: P23246
gene id (ncbi): 6421
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: PSF; POMP100; PPP1R140
category: Primary Ab
concentration: 0.5mg/ml
background: DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion.