IL-2 Receptor alpha Rabbit pAb
Cat No.: APA1003
Size：
| Product Name: | IL-2 Receptor alpha Rabbit pAb |
| Cat No.: | APA1003 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB, IHC, ICC/IF |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IHC: 1:200 ICC/IF: 1:200 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human IL-2 Receptor alpha |
| calculated molecular weight: | 31 kDa |
| observed molecular weight: | 40-80 kDa |
| genbank accession number: | P01589, P01590, P26897 |
| gene id (ncbi): | 3559, 16184, 25704 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | p55; CD25; IL2R; IMD41; TCGFR; IDDM10 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020] |