Estrogen Receptor alpha Rabbit pAb
Cat No.: APA5226
Size：
| Product Name: | Estrogen Receptor alpha Rabbit pAb |
| Cat No.: | APA5226 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,IHC,ICC/IF,FC,IP,ChIP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IHC: 1:20 ICC/IF: 1:20 FC: 1:20 IP: 1:20 ChIP: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Estrogen Receptor alpha |
| calculated molecular weight: | 66 kDa |
| observed molecular weight: | 66 kDa |
| genbank accession number: | P03372 |
| gene id (ncbi): | 2099 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | ER; ESR; Era; ESRA; ESTRR; NR3A1 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014] |