active Caspase-3 Rabbit pAb
Cat No.: APA5121
Size：
| Product Name: | active Caspase-3 Rabbit pAb |
| Cat No.: | APA5121 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,IHC,ICC/IF |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IHC: 1:20-1:500 ICC/IF: 1:100 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human active Caspase-3 |
| calculated molecular weight: | 32 kDa |
| observed molecular weight: | 17 kDa |
| genbank accession number: | P42574 |
| gene id (ncbi): | 836 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | CPP32; SCA-1; CPP32B |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer--s disease. [provided by RefSeq, Aug 2017] |