Hepcidin-25 Rabbit pAb
Cat No.: APA5088
Size：
| Product Name: | Hepcidin-25 Rabbit pAb |
| Cat No.: | APA5088 |
| source: | Rabbit |
| reactivity: | Human, Rat |
| applications: | WB |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human Hepcidin-25 |
| calculated molecular weight: | 9 kDa |
| observed molecular weight: | 9,3 kDa |
| genbank accession number: | P81172 |
| gene id (ncbi): | 57817 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | HEPC; PLTR; HFE2B; LEAP1 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014] |