C14orf169/NO66 Rabbit pAb
Cat No.: APA4972
Size：
| Product Name: | C14orf169/NO66 Rabbit pAb |
| Cat No.: | APA4972 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IP: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human C14orf169/NO66 |
| calculated molecular weight: | 71 kDa |
| observed molecular weight: | 71 kDa |
| genbank accession number: | Q9H6W3 |
| gene id (ncbi): | 79697 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates --Lys-4-- (H3K4me) and --Lys-36-- (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 --Lys-4-- (H3K4me3) and monomethylated H3 --Lys-4-- (H3K4me1) residues, while it has weaker activity for dimethylated H3 --Lys-36-- (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on --His-216--. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. |