BRSK1 Rabbit pAb
Cat No.: APA4955
Size：
| Product Name: | BRSK1 Rabbit pAb |
| Cat No.: | APA4955 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,ICC/IF |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 ICC/IF: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human BRSK1 |
| calculated molecular weight: | 85 kDa |
| observed molecular weight: | 85 kDa |
| genbank accession number: | Q8TDC3 |
| gene id (ncbi): | 84446 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | hSAD1 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at --Thr-529-- and --Ser-579--. Also regulates neuron polarization by mediating phosphorylation of WEE1 at --Ser-642-- in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. |