Caspase-1 Rabbit pAb
Cat No.: APA4824
Size：
| Product Name: | Caspase-1 Rabbit pAb |
| Cat No.: | APA4824 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IHC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:2000 IHC: 1:20-1:500 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human Caspase-1 |
| calculated molecular weight: | 45 kDa |
| observed molecular weight: | 45 kDa |
| genbank accession number: | P29466 |
| gene id (ncbi): | 834 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | ICE; P45; IL1BC |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012] |